Influence of red algal polysaccharides on neutrophils activation, cytokine synthesis and intestinal epithelial cells in vitro

Авторы

  • Ekaterina Vladimirovna SOKOLOVA G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Anna Olegovna KRAVCHENKO G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Viktoriya Nikolaevna DAVYDOVA G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Alexsandra Sergeevna KUZ’MICH G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Natalya Petrovna MISHCHENKO G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Irina Mikhailovna YERMAK G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

Ключевые слова:

carrageenans, neutrophils, cytokines, echinochromes

Аннотация

The study aim was to investigate in vitro immunomodulatory properties of carrageenans with various structural types. The data revealed that carrageenans alone did not affect the neutrophils’ size and granularity but stimulated the synthesis of cytokines in blood in vitro. Carrageenans activated neutrophils with much less potency than LPS. Carrageenans especially with low contents of sulphate groups were able to interfere with LPS in vitro resulting in reducing neutrophils activation.

Биографии авторов

Ekaterina Vladimirovna SOKOLOVA, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

PhD, Researcher

Anna Olegovna KRAVCHENKO, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

PhD, Junior Researcher

Viktoriya Nikolaevna DAVYDOVA, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

PhD, The Head of The Laboratory

Alexsandra Sergeevna KUZ’MICH, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

Researcher, MISHCHENKO Natalya Petrovna – PhD, Leading Researcher, YERMAK Irina Mikhailovna – DSc, Prinsipal Researcher

Natalya Petrovna MISHCHENKO, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

PhD, Leading Researcher

Irina Mikhailovna YERMAK, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

DSc, Prinsipal Researcher

Загрузки

Опубликован

2019-07-21

Как цитировать

SOKOLOVA, E. V., KRAVCHENKO, A. O., DAVYDOVA, V. N., KUZ’MICH, A. S., MISHCHENKO, N. P., & YERMAK, I. M. (2019). Influence of red algal polysaccharides on neutrophils activation, cytokine synthesis and intestinal epithelial cells in vitro. Вестник Дальневосточного отделения Российской академии наук, (6s), 136–137. извлечено от http://vestnikdvo.ru/index.php/vestnikdvo/article/view/363

Выпуск

№ 6s (2018): 6 Supplement

Раздел

Статьи