Influence of red algal polysaccharides on neutrophils activation, cytokine synthesis and intestinal epithelial cells in vitro

Authors

  • Ekaterina Vladimirovna SOKOLOVA G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Anna Olegovna KRAVCHENKO G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Viktoriya Nikolaevna DAVYDOVA G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Alexsandra Sergeevna KUZ’MICH G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Natalya Petrovna MISHCHENKO G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Irina Mikhailovna YERMAK G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

Keywords:

carrageenans, neutrophils, cytokines, echinochromes

Abstract

The study aim was to investigate in vitro immunomodulatory properties of carrageenans with various structural types. The data revealed that carrageenans alone did not affect the neutrophils’ size and granularity but stimulated the synthesis of cytokines in blood in vitro. Carrageenans activated neutrophils with much less potency than LPS. Carrageenans especially with low contents of sulphate groups were able to interfere with LPS in vitro resulting in reducing neutrophils activation.

Author Biographies

Ekaterina Vladimirovna SOKOLOVA, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

PhD, Researcher

Anna Olegovna KRAVCHENKO, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

PhD, Junior Researcher

Viktoriya Nikolaevna DAVYDOVA, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

PhD, The Head of The Laboratory

Alexsandra Sergeevna KUZ’MICH, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

Researcher, MISHCHENKO Natalya Petrovna – PhD, Leading Researcher, YERMAK Irina Mikhailovna – DSc, Prinsipal Researcher

Natalya Petrovna MISHCHENKO, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

PhD, Leading Researcher

Irina Mikhailovna YERMAK, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

DSc, Prinsipal Researcher

Downloads

Published

2019-07-21

How to Cite

SOKOLOVA, E. V., KRAVCHENKO, A. O., DAVYDOVA, V. N., KUZ’MICH, A. S., MISHCHENKO, N. P., & YERMAK, I. M. (2019). Influence of red algal polysaccharides on neutrophils activation, cytokine synthesis and intestinal epithelial cells in vitro. Vestnik of the Far East Branch of the Russian Academy of Sciences, (6s), 136–137. Retrieved from http://vestnikdvo.ru/index.php/vestnikdvo/article/view/363

Issue

No. 6s (2018): 6 Supplement

Section

Статьи