Mechanisms of autoimmune diseases development

Авторы

  • Georgy Alexandrovich NEVINSKY SB RAS Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia

Ключевые слова:

EAE model, C57BL/6 mice; catalytic antibodies; colony formation; hematopoietic progenitors; lymphocyte proliferation; apoptosis in different organs

Аннотация

Experimental autoimmune encephalomyelitis (EAE)-prone C57BL/6 and systemic lupus erythematosus MRL-lpr/lprmice were used as models of human autoimmune diseases (AIDs). It was shown that the development of these AIDs associated with changes in bone marrow lymphocyte proliferation and differentiation profiles of hematopoietic stem cells.In parallel these changes result in an increase in proteinuria, titers of auto-antibodies against DNA, myelin basic protein (MBP) and mouse peptide MOG35-55
, as well as in the increase in antibodies catalytic activities in the hydrolysis of DNA, MBP, and MOG35-55.
It was shown that the mechanisms of the development of the EAE and SLE are very similar.

Биография автора

Georgy Alexandrovich NEVINSKY, SB RAS Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia

DSc, Professor, The Head of the Laboratory of Reparation Enzymes

Загрузки

Опубликован

2019-07-21

Как цитировать

NEVINSKY, G. A. (2019). Mechanisms of autoimmune diseases development. Вестник Дальневосточного отделения Российской академии наук, (6s), 125–128. извлечено от http://vestnikdvo.ru/index.php/vestnikdvo/article/view/359

Выпуск

№ 6s (2018): 6 Supplement

Раздел

Статьи