Chitosan and its acyl derivatives included in liposomes protect mice against endotoxin shock

Авторы

  • Gennady Alexandrovitch NABEREZHNYKH G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Svetlana Ivanovna BAKHOLDINA G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Viktoriya Nikolaevna DAVYDOVA G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Tamara Fedorovna SOLOV’EVA G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

Ключевые слова:

endotoxin, chitosan, liposomes, anti-endotoxin effects

Аннотация

Anti-endotoxin effects of low molecular weight chitosan and its N-monoacylated derivative in solu-tion and in phospholipid liposomes was studied in mice withendotoxin shock. Preventive ten-fold oral and double intraperitoneal injection of liposomal forms of chitosans reduces the toxic effect of endotoxin (lipo-polysaccharide, LPS) in the mice and significantly increases the survival rate (83-100%) of animals in the experiment. The interaction of chitosan with LPS was shown to modulate significantly the biological activ-ity of LPS. It was shown that LPS in a complex with N-Ac-Ch-LW reduces induction of pro-inflammatory TNF-α in human blood by 40% in comparison with parent LPS, but does not affect the ability of endotoxin to stimulate blood cells to synthesize the pro-inflammatory cytokine IL-6.

Биографии авторов

Gennady Alexandrovitch NABEREZHNYKH, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

PhD, Senior Researcher

Svetlana Ivanovna BAKHOLDINA, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

PhD, Senior Researcher

Viktoriya Nikolaevna DAVYDOVA, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

PhD, The Head of The Laboratory

Tamara Fedorovna SOLOV’EVA, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

DSc, Principal Researcher

Загрузки

Опубликован

2019-07-18

Как цитировать

NABEREZHNYKH, G. A., BAKHOLDINA, S. I., DAVYDOVA, V. N., & SOLOV’EVA, T. F. (2019). Chitosan and its acyl derivatives included in liposomes protect mice against endotoxin shock. Вестник Дальневосточного отделения Российской академии наук, (6s), 118–120. извлечено от http://vestnikdvo.ru/index.php/vestnikdvo/article/view/356

Выпуск

№ 6s (2018): 6 Supplement

Раздел

Статьи