Chitosan and its acyl derivatives included in liposomes protect mice against endotoxin shock

Authors

  • Gennady Alexandrovitch NABEREZHNYKH G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Svetlana Ivanovna BAKHOLDINA G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Viktoriya Nikolaevna DAVYDOVA G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Tamara Fedorovna SOLOV’EVA G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

Keywords:

endotoxin, chitosan, liposomes, anti-endotoxin effects

Abstract

Anti-endotoxin effects of low molecular weight chitosan and its N-monoacylated derivative in solu-tion and in phospholipid liposomes was studied in mice withendotoxin shock. Preventive ten-fold oral and double intraperitoneal injection of liposomal forms of chitosans reduces the toxic effect of endotoxin (lipo-polysaccharide, LPS) in the mice and significantly increases the survival rate (83-100%) of animals in the experiment. The interaction of chitosan with LPS was shown to modulate significantly the biological activ-ity of LPS. It was shown that LPS in a complex with N-Ac-Ch-LW reduces induction of pro-inflammatory TNF-α in human blood by 40% in comparison with parent LPS, but does not affect the ability of endotoxin to stimulate blood cells to synthesize the pro-inflammatory cytokine IL-6.

Author Biographies

Gennady Alexandrovitch NABEREZHNYKH, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

PhD, Senior Researcher

Svetlana Ivanovna BAKHOLDINA, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

PhD, Senior Researcher

Viktoriya Nikolaevna DAVYDOVA, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

PhD, The Head of The Laboratory

Tamara Fedorovna SOLOV’EVA, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

DSc, Principal Researcher

Downloads

Published

2019-07-18

How to Cite

NABEREZHNYKH, G. A., BAKHOLDINA, S. I., DAVYDOVA, V. N., & SOLOV’EVA, T. F. (2019). Chitosan and its acyl derivatives included in liposomes protect mice against endotoxin shock. Vestnik of the Far East Branch of the Russian Academy of Sciences, (6s), 118–120. Retrieved from http://vestnikdvo.ru/index.php/vestnikdvo/article/view/356

Issue

No. 6s (2018): 6 Supplement

Section

Статьи