Laboratory of bioassays of the PIBOC FEB RAS: history and prospects of research on biologically active compounds. D.L. AMININ, I.G. AGAFONOVA, G.N. LIKHATSKAYA, E.L. CHAYKINA, M.M. ANISIMOV

Abstract

The main scientific direction of the laboratory of bioassays and mechanism of action of biologically active compounds of the PIBOC FEB RAS is the study on the biological activity of natural and synthetic compounds. The review examines the main achievements of the laboratory, since its foundation in 1974, to our days. The advances in the study of phyto-regulatory, antimicrobial, cytotoxic and antitumor activities; search for compounds with immunomodulatory properties; study of cytoprotectors on models of ischemia and myocardial infarction, cerebral stroke and arterial hypertension; reconstruction of biologically active compounds into bilayer lipid membranes; computer simulation of spatial structures of molecules and their interaction with intracellular and membrane targets are described.