Antiviral activity of histochrome preparation

Authors

  • Sergei Alexandrovich FEDOREEV G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Natalia Petrovna MISHCHENKO G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Elena Andreevna VASILEVA G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Natalia Vladimirovna KRYLOVA Somov Institute of Epidemiology and Microbiology, Vladivostok, Russia
  • Galina Nikolaevna LEONOVA Somov Institute of Epidemiology and Microbiology, Vladivostok, Russia
  • Vyacheslav Fedorovich LAVROV Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia

Keywords:

antiviral activity, tick-borne encephalitis virus, herpes simplex virus type 1, Echinocrome A.

Abstract

Based on the results of the MTT analysis, Histochrome® possesses antiviral activity against both tick-borne encephalitis virus (TBEV) and herpes simplex virus type 1 (HSV-1). Its IC50 against TBEV and HSV-1 at an infecting dose of 102 TCID50/ml were 21.8±2.6 μg/ml and 18.8±2.1 μg/ml, respectively (p≤0,05). When evaluating its effect at different stages of the development of these viruses, it was shown that the drug is more effective at the early stages of the virus life cycle.

Author Biographies

Sergei Alexandrovich FEDOREEV, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

DSс, The Head of the Laboratory

Natalia Petrovna MISHCHENKO, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

PhD, Leading Researcher

Elena Andreevna VASILEVA, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

Junior Researcher

Natalia Vladimirovna KRYLOVA, Somov Institute of Epidemiology and Microbiology, Vladivostok, Russia

DSc, Head of the Laboratory

Galina Nikolaevna LEONOVA, Somov Institute of Epidemiology and Microbiology, Vladivostok, Russia

DSc, Professor, Head of the Laboratory

Vyacheslav Fedorovich LAVROV, Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia

DSc, Professor, Head of the Laboratory

Downloads

Published

2019-07-22

How to Cite

FEDOREEV, S. A., MISHCHENKO, N. P., VASILEVA, E. A., KRYLOVA, N. V., LEONOVA, G. N., & LAVROV, V. F. (2019). Antiviral activity of histochrome preparation. Vestnik of the Far East Branch of the Russian Academy of Sciences, (6s), 145–151. Retrieved from http://vestnikdvo.ru/index.php/vestnikdvo/article/view/369

Issue

No. 6s (2018): 6 Supplement

Section

Статьи