Electrocardiography study of diglutathionyl analog of echinochrome on adrenaline-induced myocardial ischemia in mice

Authors

  • Anna Evgenievna ZAKIROVA G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Irina Grigorievna АGAFONOVA G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Victor Filippovich АNUFRIEV G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

Keywords:

experimental ischemia, adrenaline hydrochloride, electrocardiography, cardioprotective effect; 1,4-naphthoquinone, naphthazarin derivatives, echinochrome, histochrome

Abstract

Cardioprotective activity of 7-ethyl-2,3-diglutathionyl-6-hydroxynaphthazarin (DGE) on the model of experimental ischemia in CD1 mice was studied. The model of experimental ischemia was realized by introducing histotoxic doses of adrenaline hydrochloride. Verification of experimental ischemia was carried out by electrocardiography. Histochrome as a reference control was used. The evident cardioprotective properties of DGE were observed at a doses of 10 and 5 mg / kg

Author Biographies

Anna Evgenievna ZAKIROVA, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

Graduate Student

Irina Grigorievna АGAFONOVA, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

PhD, Senior Researcher

Victor Filippovich АNUFRIEV, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

DSc, The Head of The Laboratory

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Published

2019-07-22

How to Cite

ZAKIROVA, A. E., АGAFONOVA I. G., & АNUFRIEV V. F. (2019). Electrocardiography study of diglutathionyl analog of echinochrome on adrenaline-induced myocardial ischemia in mice. Vestnik of the Far East Branch of the Russian Academy of Sciences, (6s), 142–143. Retrieved from http://vestnikdvo.ru/index.php/vestnikdvo/article/view/367

Issue

No. 6s (2018): 6 Supplement

Section

Статьи