Liposomes as carrier for echinochrome

Authors

  • Vladimir Ivanovich GORBACH G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Viktoriya Nikolaevna DAVYDOVA G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Valeriy Petrovitch GLAZUNOV G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Irina Mikhailovna YERMAK G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

Keywords:

liposomes, carrageenan, echinochrome

Abstract

Sea urchin pigment echinochrome (6-ethyl-2,3,5,7,8-pentahydroxy-1,4-naphthoquinone) (Ech) is a natural bioactive compound with many health-promoting benefits. However, its poor water solubility and bioavailability has limited biomedical application. The inclusion of Ech in complexes with kappa-carrageenan (CRG) decreased its oxidative degradation and improved its solubility. In the present study, we used CRG as matrixes for Ech and encapsulated Ech/CRG in into liposomes. Ech did not oxidize and retain stability after the encapsulation in liposomes. According of obtained dates the entrapment efficiency of the Ech in the liposome was 46 %. The lyophilization process did not violate the native form of Ech. The size distribution and ζ-potential of the developed liposomes with and without Ech were determined.

Author Biographies

Vladimir Ivanovich GORBACH, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

PhD, Senior Researcher

Viktoriya Nikolaevna DAVYDOVA, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

PhD, The Head of The Laboratory

Valeriy Petrovitch GLAZUNOV, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

PhD, The Head of The Laboratory

Irina Mikhailovna YERMAK, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

DSc, Principal Researcher

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Published

2019-07-17

How to Cite

GORBACH, V. I., DAVYDOVA, V. N., GLAZUNOV, V. P., & YERMAK, I. M. (2019). Liposomes as carrier for echinochrome. Vestnik of the Far East Branch of the Russian Academy of Sciences, (6s), 104–105. Retrieved from http://vestnikdvo.ru/index.php/vestnikdvo/article/view/347

Issue

No. 6s (2018): 6 Supplement

Section

Статьи