Seagrass-derived fungi as a source of bioactive compounds

Authors

  • Elena Vladislavovna LESHCHENKO Far Eastern Federal University, Vladivostok, Russia; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Shamil Sheribzyanovish AFIYATULLOV G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Dmitrii Vitalievich BERDYSHEV G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

Keywords:

Penicillium thomii, Zostera marina, NMR, X‐ray, ECD spectra,TD-DFT, Mosher’s method, autophagy, NO, sesquiterpenes, polyketides

Abstract

Five new eudesmane-type sesquiterpenes – thomimarines A-E (1-5) and 12 new polyketides with “decalin” moiety – zosteropenillines A-L (6-17) were isolated from the ethylacetate extract of the fungi Penicillium thomii associated with the seagrass Zostera marina. Their structures were established based on spectroscopic methods. The absolute configurations of 1–5 and 7-10 were determined by time-dependent density functional theory (TD-DFT) calculations of ECD spectra. The absolute configuration of zosteropenilline A (6) was determined by a combination of the modified Mosher’s method, X‐ray analysis, and NOESY data. The effect of selected compounds on the viability of human drug‐resistant prostate cancer cells PC3 as well as on autophagy in these cancer cells and inhibitory effects of selected compounds on NO production in LPS‐induced RAW 264.7 murine macrophages were evaluated.

Author Biographies

Elena Vladislavovna LESHCHENKO, Far Eastern Federal University, Vladivostok, Russia; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

PhD, Researcher

Shamil Sheribzyanovish AFIYATULLOV, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

PhD, The Head of The Laboratory

Dmitrii Vitalievich BERDYSHEV, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

Researcher

Downloads

Published

2019-07-14

How to Cite

LESHCHENKO, E. V., AFIYATULLOV, S. S., & BERDYSHEV, D. V. (2019). Seagrass-derived fungi as a source of bioactive compounds. Vestnik of the Far East Branch of the Russian Academy of Sciences, (6s), 91–93. Retrieved from http://vestnikdvo.ru/index.php/vestnikdvo/article/view/323

Issue

No. 6s (2018): 6 Supplement

Section

Статьи