APETx-like peptide interaction with ASICs channels: comparative in silico study

Authors

  • Elena Alexandrovna ZELEPUGA G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Alexander Sergeevich MENSHOV G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Margarita Mikhailovna MONASTYRNAYA G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

Keywords:

sea anemone, APETx-like toxins, ion channels, ASIC3, molecular modeling

Abstract

A comparative in silico study of the interaction of APETx-like peptide from the sea anemone Heteractis crispa with ASIC3 was carried out. According to results of protein-protein docking and MD simulations, the peptide specificity is governed by their complementarity to the pharmacophores of cASIC1 and hASIC3 but not by peptide fold.

Author Biographies

Elena Alexandrovna ZELEPUGA, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

PhD, Senior Researcher

Alexander Sergeevich MENSHOV, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

Graduate Student

Margarita Mikhailovna MONASTYRNAYA, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

DSc, Leading Researcher

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Published

2019-06-20

How to Cite

ZELEPUGA, E. A., MENSHOV, A. S., & MONASTYRNAYA, M. M. (2019). APETx-like peptide interaction with ASICs channels: comparative in silico study. Vestnik of the Far East Branch of the Russian Academy of Sciences, (6s), 73–75. Retrieved from http://vestnikdvo.ru/index.php/vestnikdvo/article/view/241

Issue

No. 6s (2018): 6 Supplement

Section

Статьи