Study of analgesic and anti-inflammatory activity of HCRG21, a peptide of the sea anemone Heteractis crispa, containing S5L mutation

Authors

  • Julia V. Kozhevnikova G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Anna A. Klimovich G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

Keywords:

sea anemone peptides, Heteractis crispa, TRPV1, TRPA1, analgesia, inflammation

Abstract

The analgesic and anti-inflammatory activities of the HCRG21 peptide and its mutant analog HCRG21 S5L in the capsaicin test and in the AITC-induced nociceptive behavior model in vivo were comparatively evaluated. Unlike HCRG21, the HCRG21 S5L peptide was found to have less analgesic effect and exhibit no anti-inflammatory activity in the AITC-induced nociceptive behavior test.

Author Biographies

Julia V. Kozhevnikova, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

Junior Researcher

Anna A. Klimovich, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

Candidate of Sciences in Biology

https://orcid.org/0000-0003-4477-4203

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Published

2023-09-06

How to Cite

Kozhevnikova Ю. В., & Klimovich А. А. (2023). Study of analgesic and anti-inflammatory activity of HCRG21, a peptide of the sea anemone Heteractis crispa, containing S5L mutation. Vestnik of the Far East Branch of the Russian Academy of Sciences, (2), 144–149. Retrieved from http://vestnikdvo.ru/index.php/vestnikdvo/article/view/1088

Issue

No. 2 (2023)

Section

New scientific personnel