Antibiotic activity of Bacillus thuringiensis metabolites against intestinal bacteria and fungi

Abstract

A detailed study of the antibiotic effect of metabolites of B. thuringiensis strains on pathogenic bacteria/fungi of various taxonomic groups was carried out. The antibiotic activity of water-soluble metabolites and proteins of parasporal crystals of B. thuringiensis strains against pathogenic bacteria/fungi and molds was assessed. The cultivation conditions of the studied strains for the production of antibiotic substances were selected. Antibiotic activity of B. thuringiensis metabolites against microorganisms of the intestinal group Salmonella thyphimurium 2606, Shigella sonnei 32 and Escherichia coli ATCC 25922, phytopathogenic strain Xantomonas malvacearum, Bacillus subtilis ATCC 6633 and inhibitory and retarding effect on the growth of Staphylococcus aureus and Candida albicans, as well as test strains of fungi was revealed. The data obtained make it possible to predict the creation on their basis of antibiotic preparations with targeted action on pathogenic microorganisms of a specific taxonomic affiliation.