APETx-like peptide interaction with ASICs channels: comparative in silico study

Авторы

  • Elena Alexandrovna ZELEPUGA G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Alexander Sergeevich MENSHOV G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia
  • Margarita Mikhailovna MONASTYRNAYA G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

Ключевые слова:

sea anemone, APETx-like toxins, ion channels, ASIC3, molecular modeling

Аннотация

A comparative in silico study of the interaction of APETx-like peptide from the sea anemone Heteractis crispa with ASIC3 was carried out. According to results of protein-protein docking and MD simulations, the peptide specificity is governed by their complementarity to the pharmacophores of cASIC1 and hASIC3 but not by peptide fold.

Биографии авторов

Elena Alexandrovna ZELEPUGA, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

PhD, Senior Researcher

Alexander Sergeevich MENSHOV, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

Graduate Student

Margarita Mikhailovna MONASTYRNAYA, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia

DSc, Leading Researcher

Загрузки

Опубликован

2019-06-20

Как цитировать

ZELEPUGA, E. A., MENSHOV, A. S., & MONASTYRNAYA, M. M. (2019). APETx-like peptide interaction with ASICs channels: comparative in silico study. Вестник Дальневосточного отделения Российской академии наук, (6s), 73–75. извлечено от http://vestnikdvo.ru/index.php/vestnikdvo/article/view/241

Выпуск

№ 6s (2018): 6 Supplement

Раздел

Статьи