Secondary metabolites of micromycetes fungi of marine plants. E.V. LESHCHENKO, E.V. IVANETS, M.P. SOBOLEVSKAYA

Abstract

Thirty new secondary metabolites of various chemical nature were isolated from marine fungi of the genus Penicillum:
P. thomii KMM 4667, P. thomii Maire KMM 4675, P. thomii KMM 4674 and Penicillium sp. KMM 4672, associated with
the marine plants. The structures of the compounds were established based on NMR spectroscopy and high resolution
mass spectrometry. The absolute configurations of several compounds were determined using the Mosher’s method and by time-dependent density functional theory (TD-DFT) calculation of ECD spectra and comparison of these spectra with published data. The cytotoxic and anti-inflammatory activity of a number of isolated compounds was examined.